國家衛生研究院 NHRI:Item 3990099045/6100

NHRI > Institute of Biotechnology and Pharmaceutical Research > Shiow-Lin Pan(2009-2013) > Periodical Articles > Item 3990099045/6100

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6100

Title:	Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines
Authors:	Chen, CH;Liao, CH;Chang, YL;Guh, JH;Pan, SL;Teng, CM
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	In this study, we investigated the anticancer effect of protopine on human hormone-refractory prostate cancer (HRPC) cells. Protopine exhibited an anti-proliferative effect by induction of tubulin polymerization and mitotic arrest, which ultimately led to apoptotic cell death. The data suggest that protopine increased the activity of cyclin-dependent kinase 1 (Cdk1)/cyclin B1 complex and that contributed to cell apoptosis by modulating mitochondria-mediated signaling pathways, such as Bcl-2 phosphorylation and Mcl-1 down-regulation. In conclusion, the data suggest that protopine is a novel microtubule stabilizer with anticancer activity in HRPC cells through apoptotic pathway by modulating Cdk1 activity and Bcl-2 family of proteins.
Date:	2012-02-01
Relation:	Cancer Letters. 2012 Feb 1;315(1):1-11.
Link to:	http://dx.doi.org/10.1016/j.canlet.2011.09.042
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-3835&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000299462600001
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=81955167334
Appears in Collections:	[Shiow-Lin Pan(2009-2013)] Periodical Articles

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