國家衛生研究院 NHRI:Item 3990099045/6078
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    题名: Association of the ADRA1A gene and the severity of metabolic abnormalities in patients with schizophrenia
    作者: Cheng, C;Chiu, HJ;Loh, EW;Chan, CH;Hwu, TM;Liu, YR;Lan, TH
    贡献者: Division of Mental Health and Addiction Medicine
    摘要: Patients with schizophrenia have a higher risk of developing metabolic abnormalities and their associated diseases. Some studies found that the accumulative number of metabolic syndrome components was associated with the severity of metabolic abnormalities. The purpose of this study was to examine the roles of the ADRA1A, ADRA2A, ADRB3, and 5HT2A genes in the risk of having more severe metabolic abnormalities among patients with schizophrenia. We studied a sample of 232 chronic inpatients with schizophrenia (120 males and 112 females) to explore the associations between the four candidate genes and the severity of metabolic syndrome by accumulative number of the components. Four single nucleotide polymorphisms in the candidate genes were genotyped, including the Arg347Cys in ADRA1A, the C1291G in ADRA2A, the Try64Arg in ADRB3, and the T102C in 5HT2A. An association between the accumulative number of metabolic syndrome components and the ADRA1A gene was found after adjusting age, sex, and other related variables (p-value = 0.036). Presence of the Arg347 allele in the ADRA1A gene is a risk factor for having more severe metabolic abnormalities. These findings suggest a medical attention of closely monitoring metabolic risks for schizophrenia patients with high-risk genotypes
    日期: 2012-01
    關聯: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2012 Jan;36(1):205-210.
    Link to: http://dx.doi.org/10.1016/j.pnpbp.2011.10.011
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0278-5846&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000300073000032
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=82555176502
    显示于类别:[羅爾維(2004-2012)] 期刊論文

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