國家衛生研究院 NHRI:Item 3990099045/6066
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    题名: R432 is a key residue for the multiple functions of Ndt80p in Candida albicans
    作者: Yang, YL;Wang, CW;Leaw, SN;Chang, TP;Wang, IC;Chen, CG;Fan, JC;Tseng, KY;Huang, SH;Chen, CY;Hsiao, TY;Hsiung, CA;Chen, CT;Hsiao, CD;Lo, HJ
    贡献者: Division of Infectious Diseases;Division of Biostatistics and Bioinformatics;Institute of Biotechnology and Pharmaceutical Research
    摘要: Ndt80p is an important transcription modulator to various stress-response genes in Candida albicans, the most common human fungal pathogen in systemic infections. We found that Ndt80p directly regulated its target genes, such as YHB1, via the mid-sporulation element (MSE). Furthermore, the ndt80R432A allele, with a reduced capability to bind MSE, failed to complement the defects caused by null mutations of NDT80. Thus, the R432 residue in the Ndt80p DNA-binding domain is involved in all tested functions, including cell separation, drug resistance, nitric oxide inactivation, germ tube formation, hyphal growth, and virulence. Hence, the importance of the R432 residue suggests a novel approach for designing new antifungal drugs by blocking the interaction between Ndt80p and its targets.
    日期: 2012-03
    關聯: Cellular and Molecular Life Sciences. 2012 Mar;69(6):1011-1023.
    Link to: http://dx.doi.org/10.1007/s00018-011-0849-5
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1420-682X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000300737200011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84857641134
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