國家衛生研究院 NHRI:Item 3990099045/6055
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    题名: Increased expression of 14-3-3beta promotes tumor progression and predicts extrahepatic metastasis and worse survival in hepatocellular carcinoma
    其它题名: Increased Expression of 14-3-3β Promotes Tumor Progression and Predicts Extrahepatic Metastasis and Worse Survival in Hepatocellular Carcinoma
    作者: Liu, TA;Jan, YJ;Ko, BS;Chen, SC;Liang, SM;Hung, YL;Hsu, C;Shen, TL;Lee, YM;Chen, PF;Wang, J;Shyue, SK;Liou, JY
    贡献者: Institute of Cellular and Systems Medicine
    摘要: 14-3-3beta is implicated in cell survival, proliferation, migration, and tumor growth; however, its clinical relevance in tumor progression and metastasis have never been elucidated. To evaluate the clinical significance of 14-3-3beta, we analyzed the association of 14-3-3beta expression and clinicopathologic characteristics in primary and subsequent metastatic tumors of hepatocellular carcinoma patients. 14-3-3beta was expressed abundantly in 40 of 55 (70.7%) primary tumors. Increased 14-3-3beta expression in primary tumors predicted a higher 5-year cumulative incidence of subsequent extrahepatic metastasis, and multivariate analysis revealed 14-3-3beta overexpression was an independent risk factor for extrahepatic metastasis. Patients with increased 14-3-3beta expression in primary tumors had worse 5-year overall survival rates, and 14-3-3beta overexpression was an independent prognostic factor on Cox regression analysis. Furthermore, stably overexpressed 14-3-3beta enhanced hepatocellular carcinoma cell migration and proliferation and increased anchorage-independent cell growth. In addition, in vivo study in a nude-mice model showed tumor formation significantly increased with 14-3-3beta overexpression. In conclusion, this is the first report to show that increased 14-3-3beta expression is associated with subsequent extrahepatic metastasis and worse survival rates, as well as cancer progression of hepatocellular carcinoma. Thus, 14-3-3beta may be a novel prognostic biomarker and therapeutic target in hepatocellular carcinoma.
    日期: 2011-12
    關聯: American Journal of Pathology. 2011 Dec;179(6):2698-2708.
    Link to: http://dx.doi.org/10.1016/j.ajpath.2011.08.010
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-9440&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000298307700004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=81255199249
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