國家衛生研究院 NHRI:Item 3990099045/5977

NHRI > National Institute of Infectious Diseases and Vaccinology > Ih-Jen Su(2002-2015) > Periodical Articles > Item 3990099045/5977

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5977

Title:	An echovirus 18-associated outbreak of aseptic meningitis in Taiwan: Epidemiology and diagnostic and genetic aspects
Authors:	Tsai, HP;Huang, SW;Wu, FL;Kuo, PH;Wang, SM;Liu, CC;Su, IJ;Wang, JR
Contributors:	Division of Infectious Diseases
Abstract:	In 2006, an outbreak of aseptic meningitis was noted in Taiwan. From January to October 2006, a total of 3283 specimens collected from patients with viral infection, including 173 cerebrospinal fluid (CSF) samples, were examined for virus isolation and identification. Overall, 339 enterovirus (EV)-positive cases were identified by virus culture: echovirus 18 (E18) formed the majority (27.4%, 93 cases), followed by coxsackievirus B2 (13.8%, 47 cases) and coxsackievirus A2 (10.8%, 37 cases). The manifestations of the 93 E18 cases were aseptic meningitis (44.1%), viral exanthema (23.6%), acute tonsillitis (15.1%), acute pharyngitis (14.0%), acute gastritis (11.8%), herpangina (7.5%) and bronchopneumonia (5.3%). Of 107 E18 isolates identified, 100, 62.5 and 19% were obtained following culture in RD, MRC-5 and A549 cells, respectively. E18 was identified most frequently from throat swabs (67.2%) and less frequently from stool samples (15.9%) and CSF (16.8%). The detection rate of E18 was 78.2% from CSF, 50% from stool samples and 22.9% from throat swabs. Phylogenetic relationships among the E18 strains were examined. Analysis of the partial VP1 gene showed 3.7-23.8% variation in sequence compared with sequences from GenBank and, notably, the amino acid change V152S was detected in a protruding loop within the VP1 protein. These results indicate that a genetic variant of E18 was circulating and caused an outbreak of aseptic meningitis in Taiwan in 2006.
Date:	2011-09
Relation:	Journal of Medical Microbiology. 2011 Sep;60(9):1360-1365.
Link to:	http://dx.doi.org/10.1099/jmm.0.027698-0
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2615&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000295018700019
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80051780268
Appears in Collections:	[Ih-Jen Su(2002-2015)] Periodical Articles

Files in This Item:

File	Description	Size	Format
SCP80051780268.pdf		190Kb	Adobe PDF	321	View/Open

Loading...