國家衛生研究院 NHRI:Item 3990099045/5960
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5960


    Title: Interferon-beta Signaling Contributes to Ras Transformation
    Other Titles: Interferon-β signaling contributes to ras transformation
    Authors: Tsai, YC;Pestka, S;Wang, LH;Runnels, LW;Wan, S;Lyu, YL;Liu, LF
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: Increasing evidence has pointed to activated type I interferon signaling in tumors. However, the molecular basis for such activation and its role in tumorigenesis remain unclear. In the current studies, we report that activation of type I interferon (IFN) signaling in tumor cells is primarily due to elevated secretion of the type I interferon, IFN-beta. Studies in oncogene-transformed cells suggest that oncogenes such as Ras and Src can activate IFN-beta signaling. Significantly, elevated IFN-beta signaling in Ras-transformed mammary epithelial MCF-10A cells was shown to contribute to Ras transformation as evidenced by morphological changes, anchorage-independent growth, and migratory properties. Our results demonstrate for the first time that the type I IFN, IFN-beta, contributes to Ras transformation and support the notion that oncogene-induced cytokines play important roles in oncogene transformation.
    Date: 2011-08
    Relation: PLoS ONE. 2011 Aug;6(8):Article number e24291.
    Link to: http://dx.doi.org/10.1371/journal.pone.0024291
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000294676900040
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052301269
    Appears in Collections:[Lu-Hai Wang] Periodical Articles

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