國家衛生研究院 NHRI:Item 3990099045/5928

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5928

Title:	Levels of breast milk PBDEs from southern Taiwan and their potential impact on neurodevelopment
Authors:	Chao, HR;Tsou, TC;Huang, HL;Chang-Chien, GP
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	In vivo studies have demonstrated that prenatal or neonatal exposure to polybrominated diphenyl ethers (PBDEs) causes developmental neurotoxicity. However, there is a lack of human data. Our hypothesis was that PBDEs would result in lower infant neurodevelopment scores. This is a post-hoc analysis of previous studies. Fourteen PBDEs in 70 breast milk were analyzed using a high-resolution gas chromatograph/high-resolution mass spectrometer. Infant neurodevelopment at the age of 8-12 months was determined using the Bayley Scales of Infants and Toddlers Development, third edition (Bayley-III). The median of Sigma14PBDEs (the sum of 14 PBDE congeners) was 2.92 ng/g lipid. The Sigma14PBDE concentrations were not correlated with Bayley-III scores on cognitive, language, motor, social-emotional, or adaptive behavior scales. A significantly inverse association between brominated diphenyl ether (BDE)-209 and the cognitive scale was found after multivariate stepwise linear regression analyses (B=-0.007, adjusted R=-0.224, p=0.032). In contrast, the language scale was positively correlated with BDE-196 (B=0.096, adjusted R=0.315, p=0.002). Our results are consistent with most in vivo studies, suggesting that prenatal or postnatal exposure to BDE-209 potentially delays the neurological development.
Date:	2011-12
Relation:	Pediatric Research. 2011 Dec;70(6):596-600.
Link to:	http://dx.doi.org/10.1203/PDR.0b013e3182320b9b
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0031-3998&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000297433900009
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80855130789
Appears in Collections:	[Tsui-Chun Tsou] Periodical Articles

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