國家衛生研究院 NHRI:Item 3990099045/5919
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 925404      在线人数 : 787
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/5919


    题名: Heme oxygenase-1 in inflammation and cardiovascular disease
    作者: Wu, ML;Ho, YC;Lin, CY;Yet, SF
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Cardiovascular disease accounts for 1 of every 2.9 deaths in the United States, thus the burden of the dis-ease remains high. Given the high mortality and escalating healthcare cost for the disease, it is of urgent need to treat cardiovascular disease effectively. Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to generate car-bon monoxide, biliverdin, and iron. These reaction products of HO-1 have potent anti-inflammatory and anti-oxidative functions. Although HO-1 is expressed at low levels in most tissues under normal basal conditions, it is highly induc-ible in response to various pathophysiological stresses. Numerous studies have indicated that HO-1 induction is an adaptive defense mechanism to protect cells and tissues against injury in many disease settings. This review high-lights the role of HO-1 in inflammation and several cardiovascular diseases—atherosclerosis, myocardial infarction, graft survival after heart transplantation, and abdominal aortic aneurysm. Given that inflammation and oxidative stress are associated with development of cardiovascular disease and that HO-1 has anti-inflammatory and anti-oxidative properties, HO-1 is emerging as a great potential therapeutic target for treating cardiovascular disease
    日期: 2011-08
    關聯: American Journal of Cardiovascular Disease. 2011 Aug;1(2):150-158.
    Link to: http://www.ajcd.us/1106004A.html
    显示于类别:[林秀芳] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    NCS2011081601.pdf209KbAdobe PDF700检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈