國家衛生研究院 NHRI:Item 3990099045/5919
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 925187      Online Users : 867
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5919


    Title: Heme oxygenase-1 in inflammation and cardiovascular disease
    Authors: Wu, ML;Ho, YC;Lin, CY;Yet, SF
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Cardiovascular disease accounts for 1 of every 2.9 deaths in the United States, thus the burden of the dis-ease remains high. Given the high mortality and escalating healthcare cost for the disease, it is of urgent need to treat cardiovascular disease effectively. Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to generate car-bon monoxide, biliverdin, and iron. These reaction products of HO-1 have potent anti-inflammatory and anti-oxidative functions. Although HO-1 is expressed at low levels in most tissues under normal basal conditions, it is highly induc-ible in response to various pathophysiological stresses. Numerous studies have indicated that HO-1 induction is an adaptive defense mechanism to protect cells and tissues against injury in many disease settings. This review high-lights the role of HO-1 in inflammation and several cardiovascular diseases—atherosclerosis, myocardial infarction, graft survival after heart transplantation, and abdominal aortic aneurysm. Given that inflammation and oxidative stress are associated with development of cardiovascular disease and that HO-1 has anti-inflammatory and anti-oxidative properties, HO-1 is emerging as a great potential therapeutic target for treating cardiovascular disease
    Date: 2011-08
    Relation: American Journal of Cardiovascular Disease. 2011 Aug;1(2):150-158.
    Link to: http://www.ajcd.us/1106004A.html
    Appears in Collections:[Shaw-Fang Yet] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    NCS2011081601.pdf209KbAdobe PDF700View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback