國家衛生研究院 NHRI:Item 3990099045/5918
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    题名: Antifibrotic effects of triptolide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats
    作者: Chong, LW;Hsu, YC;Chiu, YT;Yang, KC;Huang, YT
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Triptolide (C(38)H(42)O(6)N(2), TP, a diterpene triepoxide derived from Tripterygium wilfordii Hook F.), is a potent immunosuppresive and antiinflammatory agent. The present study investigated whether TP exerted antihepatofibrotic effects in vitro and in vivo. A cell line of rat hepatic stellate cells (HSC-T6) was stimulated with tumor necrosis factor-alpha (TNF-alpha) or transforming growth factor (TGF)-beta 1. The inhibitory effects of TP on the nuclear factor-kappa B (NF kappa B) signaling cascade and fibrosis markers, including alpha-smooth muscle actin (alpha-SMA) and collagen, were assessed. An in vivo therapeutic study was conducted in dimethylnitrosamine (DMN)-treated rats. The rats were randomly assigned to one of three groups: control rats, DMN rats receiving vehicle only and DMN rats receiving TP (20 mu g/kg). Treatment was given by gavage twice daily for 3 weeks starting 1 week after the start of DMN administration. TP (5-100 nM) concentration-dependently inhibited the NF kappa B transcriptional activity induced by TNF-alpha, lipopolysaccharide and phorbol 12-myristate 13-acetate in HSC-T6 cells. In addition, TP also suppressed TNF-alpha and TGF-beta 1-induced collagen deposition and alpha-SMA secretion in HSC-T6 cells. In vivo, TP treatment significantly reduced hepatic fibrosis scores, collagen contents, IL-6 and TNF-alpha levels, and the number of alpha-SMA and NF kappa B-positive cells in DMN rats. The results showed that TP exerted antifibrotic effects in both HSC-T6 cells and DMN rats.
    日期: 2011-07
    關聯: Phytotherapy Research. 2011 Jul;25(7):990-999.
    Link to: http://dx.doi.org/10.1002/ptr.3381
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0951-418X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000293031400006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84860396737
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