國家衛生研究院 NHRI:Item 3990099045/5874
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5874


    Title: Cytotoxic steroidal saponins from agave sisalana
    Authors: Chen, PY;Chen, CH;Kuo, CC;Lee, TH;Kuo, YH;Lee, CK
    Contributors: National Institute of Cancer Research
    Abstract: Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC(50) values of 1.2, 3.8, and 1.5 mu M, respectively.
    Date: 2011-06
    Relation: Planta Medica. 2011 Jun;77(9):929-933.
    Link to: http://dx.doi.org/10.1055/s-0030-1250672
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0032-0943&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000292028900009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79958807490
    Appears in Collections:[Ching-Chuan Kuo] Periodical Articles

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