國家衛生研究院 NHRI:Item 3990099045/5858
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    题名: Impact of derepressed AmpC beta-Lactamase ACT-9 on the clinical efficacy of ertapenem
    其它题名: Impact of Derepressed AmpC β-Lactamase ACT-9 on the Clinical Efficacy of Ertapenem
    作者: Lee, YT;Chen, TL;Siu, LK;Chen, CP;Fung, CP
    贡献者: Division of Infectious Diseases
    摘要: An in vivo development of Pantoea agglomerans mutants (isolates PA2-4) with reduced ertapenem susceptibility from isolate PA1 was associated with an inadequate clinical response to ertapenem therapy. All the four isolates harbored the bla(ACT-9) AmpC beta-lactamase gene. However, a loss-of-function mutation in the ampD gene in PA2-4, but not PA1, led to derepressed ACT-9. The reduced ertapenem susceptibility caused by derepressed ACT-9 was confirmed with an ampD-knockout mutant of PA1.
    日期: 2011-09
    關聯: Antimicrobial Agents and Chemotherapy. 2011 Sep;55(9):4440-4442.
    Link to: http://dx.doi.org/10.1128/aac.00271-11
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0066-4804&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000293953900074
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80051808646
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