國家衛生研究院 NHRI:Item 3990099045/5857
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    题名: Effect of spacer sequences between blaCTX-M and ISEcp1 on blaCTX-M expression
    其它题名: Effect of spacer sequences between bla(CTX-M) and ISEcp1 on bla(CTX-M) expression
    作者: Ma, L;Siu, LK;Lu, PL
    贡献者: Division of Infectious Diseases
    摘要: Spacer sequences sized 42 and 127 bp, respectively, between ISEcp1 insertion sequence and the bla(CTX-M) were observed in Klebsiella pneumoniae. However, it is not known whether different spacers in the upstream of bla(CTX-M) and a promoter within the 127 bp spacer will influence cephalosporin resistance. Three recombinant plasmids with different spacers and with or without the ISEcp1 were constructed to compare the bla(CTX-M-3) expression and susceptibility to cephalosporins. Our experiment revealed enhanced bla(CTX-M-3) expression and a relatively high level resistance to cefotaxime and cefepime in recombinant plasmid IS42CTX-M-3, which contained ISEcp1 and the 42 bp spacer. Minor difference in bla(CTX-M-3) expression was observed in recombinants IS127CTX-M-3 and 127CTX-M-3, which contained a 127 bp spacer with or without ISEcp1, respectively. In conclusion, the promoter within ISEcp1 and a shorter spacer (42 bp but not 127 bp) between ISEcp1 and bla(CTX-M) are necessary for a high level bla(CTX-M-3) expression.
    日期: 2011-12
    關聯: Journal of Medical Microbiology. 2011 Dec;60(12):1787-1792.
    Link to: http://dx.doi.org/10.1099/jmm.0.033910-0
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2615&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000298218100011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=81355132820
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