國家衛生研究院 NHRI:Item 3990099045/5856
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    題名: Identification of the third type of PVL phage in ST59 methicillin-resistant Staphylococcus aureus (MRSA) strains
    作者: Zhang, M;Ito, T;Li, S;Xun, JJ;Takeuchi, F;Lauderdale, TL;Higashide, M;Hiramatsu, K
    貢獻者: Division of Infectious Diseases
    摘要: The genes lukS-PV and lukF-PV for Panton-Valentine leukocidin (PVL) that confers high virulence to Staphylococcal aureus are located on the prophages (PVL phages), which have been classified into group 1 and 2 sfi21-like Siphoviridae. We report novel PVL phages lysogenized in ST59 MRSA strains isolated in Japan (JCSC7247) and Taiwan (JCSC5967). The genomes of phi7247 PVL and phi5967PVL showed more than 99% identity, and the regions containing the five genes located at both ends of the prophages, int (integrase), hol (holin), ami (amidase), lukS-PV and lukF-PV are highly homologous to extant PVL phages. However, the genes for the structural module are less homologous to them, but are highly homologous to those of non-PVL phages belonging to group 3 sfi21-like Siphoviridae, e.g., phiN315. Subsequent PCR identification and nucleotide sequencing of additional 11 Taiwanese ST59 MRSA isolates suggested they all carry the same phage as phi5967PVL, which differed from phi7247PVL by a single base. This study adds evidence to the notion that novel PVL phages would be generated through illegitimate recombination events by acquiring the region at which hol, ami, luk, and int genes would line up upon lytic growth, and suggested that PVL positive MRSA clones emerged worldwide may carry distinct phages.
    日期: 2011-10
    關聯: FEMS Microbiology Letters. 2011 Oct;323(1):20-28.
    Link to: http://dx.doi.org/10.1111/j.1574-6968.2011.02355.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0378-1097&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000295097700003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052735712
    顯示於類別:[楊采菱] 期刊論文

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