Background: Caffeic Acid Phenethyl Ester (CAPE), a bioactive component of honeybee hive propolis, is known to exhibit anti-mitogenic, anti-carcinogenic, anti-inflammatory, anti-viral and immuno-modulatory properties. Result: In this review study, we summarize the known effect and possible mechanism of CAPE on suppressing proliferation of different cancer cells as well as inhibiting growth and metastasis of different tumors. Conclusion: Recent observations suggest CAPE administration as a potential adjuvant therapy for several types of cancer.
