國家衛生研究院 NHRI:Item 3990099045/5851
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    题名: Aptamer-conjugated DNA icosahedral nanoparticles as a carrier of doxorubicin for cancer therapy
    作者: Chang, M;Yang, CS;Huang, DM
    贡献者: Center for Nanomedicine Research
    摘要: DNA can be used to nanofabricate three-dimensional (3D) polyhedra. A variety of applications of 3D DNA assemblies have been proposed. Drug encasulation and intracellular delivery using DNA nanoparticles, however, have remained a challenge. Here, we create a distinct five-point-star motif and aptamer-conjugated six-point-star motif using well-used primer sequences to intermolecularly construct DNA icosahedra as a nanocarrier for doxorubicin. Aptamer-conjugated doxorubicin-intercalated DNA icosahedra (Doxo@Apt-DNA-icosa) show an efficient and specific internalization for killing epithelial cancer cells.
    日期: 2011-08
    關聯: ACS Nano. 2011 Aug;5(8):6156-6163.
    Link to: http://dx.doi.org/10.1021/nn200693a
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1936-0851&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000294085400012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052040413
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