國家衛生研究院 NHRI:Item 3990099045/5811
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 908579      在线人数 : 1032
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/5811


    题名: Alpha1-antitrypsin deficiency and conformational diseases
    其它题名: α1-抗胰蛋白酶缺乏症與蛋白質構型變異疾病
    作者: Chang, YP;Chang, WS;W. Chu, YH
    贡献者: National Institute of Cancer Research
    摘要: Abnormal protein aggregation is responsible for numerous diseases such as Alzheimer’s disease, Parkinson’s disease and α1-antitrypsin deficiency (AATD). This category of diseases is now recognized as conformational diseases. α1-Antitrypsin is the archetype of the serine protease inhibitor (serpin) superfamily, and its physiological role is a suicide substrate toward its cognate enzyme neutrophil elastase. Through an unique conformational transition, the snared elastase is neutralized and the alveolar matrices in lungs are protected from destruction. However, dysfunctional mutations can result in a loss of inhibitory activity or allow spontaneous and inappropriate intermolecular polymerization ofα1-antitrypsin, ultimately leading to emphysema and cirrhosis. Insights of the mechanism of diseases offer a promising anti-protein polymerization strategy. Previous studies have shown that synthetic peptides can anneal to Zα1-antitrypsin and block polymerization. Most recently, we have developed a combinatorial approach for the discovery of anti-protein polymerization ligands, valuable for the design of therapeutic agents
    日期: 2005-09
    關聯: 化學. 2005 Sep;63(3):419-430.
    Link to: http://readopac1.ncl.edu.tw/nclJournal/search/detail.jsp?sysId=0005798517&dtdId=000040&search_type=detail&la=ch
    显示于类别:[張文祥] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    NCA2011062102.pdf1005KbAdobe PDF523检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈