國家衛生研究院 NHRI:Item 3990099045/5786
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5786


    Title: Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood
    Authors: Hong, X;Wang, G;Liu, X;Kumar, R;Tsai, H-J;Arguelles, L;Hao, K;Pearson, C;Ortiz, K;Bonzagni, A;Apollon, S;Fu, L;Caruso, D;Pongracic, JA;Schleimer, R;Holt, PG;Bauchner, H;Wang, X
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Background:The effect of breast-feeding on the development of allergic disease is uncertain. There are no data that show whether this relationship varies by individual genotypes. Objective:We sought to evaluate the effect of breast-feeding and gene–breast-feeding interactions on food sensitization (FS) in a prospective US birth cohort. Methods:This study included 970 children who were prospectively followed since birth. Breast-feeding history was obtained from a standardized questionnaire interview. FS was defined as a specific IgE level of 0.35 kUA/L or greater to any of 8 common food allergens. Eighty-eight potentially functional single nucleotide polymorphisms (SNPs) were genotyped from 18 genes involved in innate immunity or TH1/TH2 balance. Logistic regression models were used to test the effects of breast-feeding and gene–breast-feeding interactions on FS, with adjustment for pertinent covariates. Results:Children who were ever breast-fed (n = 739), including exclusively breast-fed children, were at a 1.5 (95% CI, 1.1-2.1; P = .019) times higher risk of FS than never breast-fed children (n = 231). This association was significantly modified by rs425648 in the IL-12 receptor β1 gene (IL12RB1; P for interaction = .0007): breast-feeding increased the risk of FS (odds ratio, 2.0; 95% CI, 1.4-3.1; P = .0005) in children carrying the GG genotype but decreased the risk (odds ratio, 0.6; 95% CI, 0.3-1.4; P = .252) in children carrying the GT/TT genotype. Similar interactions were observed for SNPs in the Toll-like receptor 9 (TLR9; rs352140) and thymic stromal lymphopoietin (TSLP; rs3806933) genes. The interaction between the combined genotypes of the 3 SNPs and breast-feeding on FS was even stronger (P for interaction < 10−5). Conclusion:Our data suggest that the effect of breast-feeding on FS was modified by SNPs in the IL12RB1, TLR9, and TSLP genes both individually and jointly. Our findings underscore the importance of considering individual genetic variations in assessing this relationship.
    Date: 2011-08
    Relation: Journal of Allergy and Clinical Immunology. 2011 Aug;128(2):374-381.
    Link to: http://dx.doi.org/10.1016/j.jaci.2011.05.007
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0091-6749&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000293280800019
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79960977186
    Appears in Collections:[Hui-Ju Tsai] Periodical Articles

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