國家衛生研究院 NHRI:Item 3990099045/5749
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5749


    Title: Epigenetic activation of human kallikrein 13 enhances malignancy of lung adenocarcinoma by promoting N-cadherin expression and laminin degradation
    Authors: Chou, RH;Lin, SC;Wen, HC;Wu, CW;Chang, WS
    Contributors: National Institute of Cancer Research
    Abstract: The tissue kallikrein (KLK) family contains 15 genes (KLK1-KLK15) tandemly arranged on chromosome 19q13.4 that forms the largest cluster of contiguous protease genes in the human genome. Here, we provide mechanistic evidence showing that the expression of KLK13, one of the most recently identified family members, is significantly up-regulated in metastatic lung adenocarcinoma. Whilst overexpression of KLK13 resulted in an increase in malignant cell behavior, knockdown of its endogenous gene expression caused a significant decrease in cell migratory and invasive properties. Functional studies further demonstrated that KLK13 is activated via demethylation of its upstream region. The elevated KLK13 protein then enhances the ability of tumor cells to degrade extracellular laminin that, subsequently, facilitates cell metastatic potential in the in vivo SCID mouse xenograft model. KLK13 was also found to induce the expression of N-cadherin to help promote tumor cell motility. Together, these results reveal the enhancing effects of KLK13 on tumor cell invasion and migration, and that it may serve as a diagnostic/prognostic marker and a potential therapeutic target for lung cancer.
    Date: 2011-06-10
    Relation: Biochemical and Biophysical Research Communications. 2011 Jun;409(3):442-447.
    Link to: http://dx.doi.org/10.1016/j.bbrc.2011.05.022
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-291X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000292059500015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80955180553
    Appears in Collections:[Wun-Shaing Wayne Chang] Periodical Articles
    [Cheng-Wen Wu(1996-2008)] Periodical Articles

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