國家衛生研究院 NHRI:Item 3990099045/5722
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    题名: Tonsillar CD4(+)FOXP3(+) T-regulatory cell dynamics in primary EBV infection
    其它题名: Tonsillar CD4+FOXP3+ T-regulatory cell dynamics in primary EBV infection
    作者: Chow, YH;Chang, HW;Sia, R;Chong, P;Sia, C
    贡献者: Division of Vaccine Research and Development
    摘要: CD8(+) lymphocytosis is recognized as the primary immunopathological response generated in primary EBV infection that may manifest itself as a benign lymphoproliferative disorder, infectious mononucleosis (IM). While CD4(+)FOXP3(+) T-regulatory cells (Treg cells) are well accepted to inhibit T-cell responses, it is puzzling why massive expansion of CD8(+) lymphocytes still occurs despite CD4(+)FOXP3(+) Treg cells are localized in tonsils, which are the port of entry of the virus. Understanding the interplay between the virologic and immunologic events that take place in tonsils in primary EBV infection is necessary to comprehend why IM preferentially develops in adolescents and the dynamics of CD4(+) Treg cell change that may occur in virus/pathogen infection in a broader setting.
    日期: 2011-05
    關聯: Immunologic Research. 2011 May;50(1):97-101.
    Link to: http://dx.doi.org/10.1007/s12026-010-8174-x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0257-277X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000290042700009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79955635844
    显示于类别:[周彥宏] 期刊論文
    [莊再成] 期刊論文
    [謝鐸源(2006-2014)] 期刊論文

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