國家衛生研究院 NHRI:Item 3990099045/5716
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    题名: Imaging the cellular uptake of tiopronin-modified gold nanoparticles
    作者: Cai, X;Chen, HH;Wang, CL;Chen, ST;Lai, SF;Chien, CC;Chen, YY;Kempson, IM;Hwu, Y;Yang, CS;Margaritondo, G
    贡献者: Center for Nanomedicine Research
    摘要: Well-dispersed gold nanoparticles (NP) coated with tiopronin were synthesized by X-ray irradiation without reducing agents. High-resolution transmission electron microscopy shows that the average core diameters of the NPs can be systematically controlled by adjusting the tiopronin to Au mole ratio in the reaction. Three methods were used to study the NP uptake by cells: quantitative measurements by inductively coupled plasma mass spectrometry, direct imaging with high lateral resolution transmission electron microscopy and transmission X-ray microscopy. The results confirmed that the NP internalization mostly occurred via endocytosis and concerned the cytoplasm. The particles, in spite of their small sizes, were not found to arrive inside the cell nuclei. The synthesis without reducing agents and solvents increased the biocompatibility as required for potential applications in analysis and biomedicine in general.
    日期: 2011-08
    關聯: Analytical and Bioanalytical Chemistry. 2011 Aug;401(3):809-816.
    Link to: http://dx.doi.org/10.1007/s00216-011-4986-3
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1618-2642&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000292970200005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052572374
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