國家衛生研究院 NHRI:Item 3990099045/5634
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12190/12972 (94%)
造訪人次 : 1061888      線上人數 : 1022
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/5634


    題名: A hierarchical study on load/release kinetics of guest molecules into/from mesoporous silica thin films
    作者: Lian, HY;Liang, YH;Yamauchi, Y;Wu, KCW
    貢獻者: Division of Medical Engineering Research
    摘要: The load/release behaviors of a fluorescent molecule, fluorescein isothiocyanate (FITC), using mesoporous silica thin films as hosts are investigated through a hierarchical study of three parameters (i.e., loading methods, porous structures, and morphologies) from microscopic to macroscopic levels. Three different methods, physical adsorption (AD), entrapment (EN), and cleavable binding (CB), were used to load FITC into three-dimensional hexagonal (3DH) mesoporous silica thin films. On the basis of the results of fluorescence spectroscopies, we found a diffusion-controlled release (first-order release) for the AD-3DH case, a dissolution-controlled release (zero-order release) for the EN-3DH case, and a stimuli-responsive release for the CB-3DH case. Mesoporous silica thin films with two kinds of mesostructures, two-dimensional hexagonal (2DH) and 3DH, were successfully synthesized. The adsorption and release kinetics, including the dissociation constant (K-d) and half-life value (t(1/2)), for the 2DH and 3DH films are similar due to the existence of micropores in both cases, although the 2DH film exhibited a larger maximum adsorption amount (N-ads(infinity)) than the 3DH film. Linear and circular patterns with a 3DH mesostructure were fabricated. Compared with the 3DH film, the patterns exhibit more external pore entrances, resulting in easier adsorption and desorption of FITC molecules. Unlike conventional mesoporous solids, we demonstrated that mesoporous thin films with the desired loading method, mesostructure, and morphology could serve as a new substrate for controlled release systems.
    日期: 2011-04
    關聯: Journal of Physical Chemistry C. 2011 Apr;115(14):6581-6590.
    Link to: http://dx.doi.org/10.1021/jp110852p
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-7447&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000289215400054
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79953737934
    顯示於類別:[吳嘉文] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000289215400054.pdf4492KbAdobe PDF425檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋