國家衛生研究院 NHRI:Item 3990099045/5628
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5628


    Title: Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: application of the copper-mediated Ullmann-type arylation
    Authors: Lee, HY;Chang, JY;Chang, LY;Lai, WY;Lai, MJ;Shih, KH;Kuo, CC;Chang, CY;Liou, JP
    Contributors: National Institute of Cancer Research
    Abstract: In an attempt to mimic the 3,4,5-trimethoxyphenyl-Z-stilbene moiety of combretastatin A-4, a series of N-aryl-5,6,7-trimethoxyindoles were synthesized via copper-catalyzed Ullmann-type N-arylation through the corresponding 5,6,7-trimethoxyindole and aryl halides. These synthesized compounds demonstrated potent antiproliferative activity providing a novel skeleton for potent tubulin polymerization inhibitors.
    Date: 2011-04
    Relation: Organic and Biomolecular Chemistry. 2011 Apr;9(9):3154-3157.
    Link to: http://dx.doi.org/10.1039/c0ob01038c
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1477-0520&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000289488000012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79954441934
    Appears in Collections:[Ching-Chuan Kuo] Periodical Articles
    [Jang-Yang Chang] Periodical Articles

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