國家衛生研究院 NHRI:Item 3990099045/5615
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 854787      線上人數 : 810
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/5615


    題名: The association between total urinary arsenic concentration and renal dysfunction in a community-based population from central Taiwan
    作者: Chen, JW;Chen, HY;Li, WF;Liou, SH;Chen, CJ;Wu, JH;Wang, SL
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: Arsenic (As) is an important environmental toxicant that can cause cancer and cardiovascular disease, but the relationship between As exposure and renal dysfunction is not clear. The aim of this study is to examine the association between As exposure and renal dysfunction in a community-based population in central Taiwan. One thousand and forty-three subjects were recruited between 2002 and 2005. The risk for type 2 diabetes was increased by 2-fold (p < 0.05) in subjects with total urinary As (U-As) > 75 μg g-1 creatinine as compared with subjects whose U-As was ?35 μg g-1 creatinine after the adjustment for potential confounders. The adjusted odds ratio for an abnormal β2 microglobulin (B2MG > 0.154 mg L-1) was significantly higher in subjects with U-As > 35 μg g-1 creatinine as compared with the reference group adjusted for age, sex, living area, cigarette smoking, diabetes, and hypertension. The risk for abnormal B2MG and estimated glomerular filtration rate (eGFR < 90 mL min-1 (1.73 m2)-1) was both increased around 2-fold (p < 0.05) in subjects with U-As > 75 μg g-1 creatinine as compared with those with U-As ? 35 μg g-1 creatinine adjusted for all the risk factors plus lead (Pb), cadmium and nickel. The prevalence of abnormal B2MG was 4.82 times higher in subjects with both over the median levels of U-As (85.1 μg L-1) and urinary Pb (18.9 μg L-1) as compared to both lower than the median (p < 0.001). These results indicate that U-As might relate to renal dysfunction even other important risk factors were taken into account. Follow-up studies for causal inference are warranted.
    日期: 2011-06
    關聯: Chemosphere. 2011 Jun;84(1):17-24.
    Link to: http://dx.doi.org/10.1016/j.chemosphere.2011.02.091
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0045-6535&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000292416400003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79956087521
    顯示於類別:[王淑麗] 期刊論文
    [劉紹興] 期刊論文
    [李婉芬(2001-2009)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SCP79953107409.pdf403KbAdobe PDF887檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋