國家衛生研究院 NHRI:Item 3990099045/5609
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    题名: Profiling of influenza viruses by high-throughput carbohydrate membrane array
    作者: Lao, WI;Wang, YF;Kuo, YD;Lin, CH;Chang, TC;Su, IJ;Wang, JR;Chang, CF
    贡献者: Division of Infectious Diseases
    摘要: Background: Carbohydrate-protein interactions participate in many biological functions. To characterize the binding interactions represents a longstanding challenge. Method: We developed a glycan membrane array to study the interactions of carbohydrates with lectins, proteins and viruses, including 17 lectins, four antibodies (that are specific to different Lewis antigens), one recombinant H5N1 hemagglutinin, and five influenza B clinical isolates. Results: The results were found to be comparable to previous reports, indicating the efficacy and reliability of our developed method. Conclusion: This carbohydrate membrane array represents a convenient, reliable and low-cost method to examine the carbohydrate-binding features of various proteins, high-throughput drug screening and the glycan-binding surveillance of influenza viruses.
    日期: 2011-03
    關聯: Future Medicinal Chemistry. 2011 Mar;3(3):283-96.
    Link to: http://dx.doi.org/10.4155/fmc.10.290
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1756-8919&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000288882700008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79953243313
    显示于类别:[蘇益仁(2002-2015)] 期刊論文

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