國家衛生研究院 NHRI:Item 3990099045/5596
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    题名: Synthesis of 3,3-dimethylglutamic acid derivatives as DPP-IV inhibitors and evaluation of their chemical stability
    作者: Hsu, T;Tsai, TY;Tseng, YJ;Chiou, MC;Lu, CT;Chao, YS;Jiaang, WT
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: A novel five-step synthesis of Boc-3,3-dimethylglutamic acid a-ethyl ester 11 is reported. All the steps are high yielding and simple to carry out. By use of the 3,3-dimethylglutamic acid building block, we successfully discovered a novel class of DPP-IV inhibitors, Glu-Pro-Nitrile dipeptide mimics 2, with high potency (IC50 < 40 nM). The consequence of 3,3-dimethyl substituent on the rate of intramolecular cyclization between N-terminal amine and 5-position amide bond in different buffer solutions was also evaluated.
    日期: 2011-02
    關聯: Journal of the Chinese Chemical Society. 2011 Feb;58(1):108-117.
    Link to: http://chemistry.org.tw/public_jour_elec.php?volume=&pageno=&qstring=&flag=&isget=T&page=2
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-4536&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000288837600017
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79955525989
    显示于类别:[蔣維棠] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [徐祖安] 期刊論文

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