國家衛生研究院 NHRI:Item 3990099045/5497
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5497


    Title: EGFR L858R mutation and polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients
    Authors: Yang, SY;Yang, TY;Chen, KC;Li, YJ;Hsu, KH;Tsai, CR;Chen, CY;Hsu, CP;Hsia, JY;Chuang, CY;Tsai, YH;Chen, KY;Huang, MS;Su, WC;Chen, YM;Hsiung, CA;Shen, CY;Chang, GC;Yang, PC;Chen, CJ
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: PURPOSE: To assess whether polymorphisms of genes related to estrogen biosynthesis and metabolism are associated with EGFR mutations. EXPERIMENTAL DESIGN: We studied 617 patients with lung adenocarcinoma, including 302 never-smoking women. On the basis of multiple candidate genes approach, the effects of polymorphisms of CYP17, CYP19A1, ERalpha and COMT in association with the occurrence of EGFR mutations were evaluated using logistic regression analysis.RESULTS: In female never-smokers, significant associations with EGFR L858R mutation were found for the (TTTA)n repeats in CYP19A1 (odds ratio [OR], 2.6; 95% confidence interval [CI], 1.2-5.7 for one or two alleles with (TTTA)n repeats >7 compared to both alleles with (TTTA)n repeats <==7), and the rs2234693 in ERalpha (OR,2.1; 95% CI, 1.1-4.0 for C/T and C/C genotypes compared to T/T genotype). The C/C genotype (vs. T/T genotype) of ERalpha was significantly associated with EGFR L858R mutation (OR, 3.0; 95% CI, 1.1-8.1), in-frame deletion (OR, 2.9; 95% CI, 1.1-7.6) and other mutations (OR, 4.3; 95% CI, 1.3-14.0). The genotype of COMT rs4680 was significantly associated with EGFR L858R mutation in female and male never-smokers showing OR's (95% CI) of 1.8 (1.0-3.2) and 3.6 (1.1-11.3), respectively, for genotypes G/A and G/G compared to genotype A/A. The number of risk alleles of CYP17, CYP19A1, ERalpha and COMT was associated with an increasing OR of EGFR L858R mutation in female never-smokers (P=.0002 for trend).CONCLUSIONS: The L858R mutation of EGFR is associated with polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients.
    Date: 2011-04
    Relation: Clinical Cancer Research. 2011 Apr;17(8):2149-2158.
    Link to: http://dx.doi.org/10.1158/1078-0432.CCR-10-2045
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1078-0432&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000289555500010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79954616695
    Appears in Collections:[Chao A. Hsiung] Periodical Articles

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