國家衛生研究院 NHRI:Item 3990099045/5490
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    题名: The deubiquitylating enzyme, Cops6, regulates different developmental processes during early zebrafish embryogenesis
    作者: Tse, WKF;You, MS;Ho, SHK;Jiang, YJ
    贡献者: Division of Molecular and Genomic Medicine
    摘要: Zebrafish cops6 encodes a putative deubiquitylating enzyme (DUB) that belongs to the JAMM family. It consists of 297 amino acids and includes the Mov34/MPN/PAD-1 (PF01398) domain. Ubiquitylation is involved in many cellular processes and deconjugation of ubiquitinmodified substrates is important to maintain a sufficient amount of free ubiquitin in the cell. Here, we report our findings regarding the general function of the cops6 gene, as a continuation of our previous studies involving DUB knockdown screening. We have found that cops6 plays different roles in early embryonic development in the zebrafish, including dorsoventral patterning, convergent extension movement and brain formation. In addition, our findings indicate that cops6 plays an anti-apoptotic role during segmentation. Overall, the present study that consolidates our previous work on zebrafish DUB genes, corroborates the hypothesis of multi-functional roles for DUB genes during development.
    日期: 2011-03
    關聯: International Journal of Developmental Biology. 2011 Mar;55(1):19-24.
    Link to: http://dx.doi.org/10.1387/ijdb.103089wt
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0214-6282&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000291839800003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79952098367
    显示于类别:[江運金] 期刊論文

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