國家衛生研究院 NHRI:Item 3990099045/5482
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    题名: Pharmaceutical poisoning exposure and outcome analysis in children admitted to the pediatric emergency department
    作者: Lin, YR;Liu, TH;Liu, TA;Chang, YJ;Chou, CC;Wu, HP
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Background: Pharmaceutical involved in childhood poisoning varies, and treatment of poison exposure can be a challenge for primary physicians when children are unconscious or histories are lacking. Knowledge of the clinical manifestations and prognosis of poisoning will help primary physicians to perform appropriate clinical assessments. In this study, we aim to report on patient characteristics, outcomes, and clinical features of pediatric poisoning in the emergency department. Methods: We retrospectively evaluated the medical records of 87 children younger than 18 years of age and presented to the emergency department with pharmaceutical poisoning (2001-2008). The detailed categories of pharmaceutical were reported, and their associations with patient outcomes were analyzed. Furthermore, children were divided into two groups, based on the reasons for poison exposure (accidental or intentional poisoning). Clinical features and outcomes between accidental or intentional poisoning were analyzed, and the cut-off age for high risk of intentional poison was also calculated. Results: Age groups of adolescents (48.3%) and preschool age (32.2%) children were the major representation. Neurologic system agents (48.3%) and analgesics (18.4%) were the most common causes of poisoning. Among the two major agents above, anxiolytic/hypnotic drugs (lorazepam) and acetaminophen were the most frequent causes. Of all children, 70.1% had duration of major symptoms for ≦1 day, and intentional poisoning significantly caused longer duration of hospital stay than accidental poisoning (p = 0.008). Moreover, female gender (p < 0.001), older age (p < 0.001), and analgesics (p = 0.008) were more predominantly associated with intentional poisoning in children, and the cut-off age for high risk of intentional poisoning was over 10.5 years. Conclusion: Neurologic system agents and analgesics were responsible for the majority of cases. Intentional poisoning caused longer hospital length of stay than accidental poisoning, and the factors associated with intentional poisoning were older age, female, and neurologic system agents.
    日期: 2011-02
    關聯: Pediatrics and Neonatology. 2011 Feb;52(1):11-17.
    Link to: http://dx.doi.org/10.1016/j.pedneo.2010.12.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1875-9572&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000288631200004
    https://www.webofscience.com/wos/woscc/full-record/WOS:000288631200004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79952444648
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