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http://ir.nhri.org.tw/handle/3990099045/5457
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| Title: | Familial tendency and risk of nasopharyngeal carcinoma in Taiwan: Effects of covariates on risk |
| Authors: | Hsu, WL;Yu, KJ;Chien, YC;Chiang, CJ;Cheng, YJ;Chen, JY;Liu, MY;Chou, SP;You, SL;Hsu, MM;Lou, PJ;Wang, CP;Hong, JH;Leu, YS;Tsai, MH;Su, MC;Tsai, ST;Chao, WY;Ger, LP;Chen, PR;Yang, CS;Hildesheim, A;Diehl, SR;Chen, CJ |
| Contributors: | National Institute of Cancer Research |
| Abstract: | In the present study, the authors compared the long-term risk of nasopharyngeal carcinoma (NPC) of male participants in an NPC multiplex family cohort with that of controls in a community cohort in Taiwan after adjustment for anti-Epstein-Barr virus (EBV) seromarkers and cigarette smoking. A total of 43 incident NPC cases were identified from the 1,019 males in the NPC multiplex family cohort and the 9,622 males in the community cohort, for a total of 8,061 person-years and 185,587 person-years, respectively. The adjusted hazard ratio was 6.8 (95% confidence interval (CI): 2.3, 20.1) for the multiplex family cohort compared with the community cohort. In the evaluation of anti-EBV viral capsid antigen immunoglobulin A and anti-EBV deoxyribonuclease, the adjusted hazard ratios were 2.8 (95% CI: 1.3, 6.0) and 15.1 (95% CI: 4.2, 54.1) for those positive for 1 EBV seromarker and positive for both seromarkers, respectively, compared with those negative for both EBV seromarkers. The adjusted hazard ratio was 31.0 (95% CI: 9.7, 98.7) for participants who reported a family history of NPC and who were anti-EBV-seropositive compared with individuals without such a history who were anti-EBV-seronegative. The findings suggest that both family history of NPC and anti-EBV seropositivity are important determinants of subsequent NPC risk and that the effect of family history on NPC risk cannot be fully explained by mediation through EBV serologic responses. |
| Date: | 2011-02 |
| Relation: | American Journal of Epidemiology. 2011 Feb;173(3):292-299. |
| Link to: | http://dx.doi.org/10.1093/aje/kwq358 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-9262&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000286463300005 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79251497662 |
| Appears in Collections: | [陳振陽] 期刊論文
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| ISI000286463300005.pdf | | 135Kb | Adobe PDF | 1076 | View/Open |
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