國家衛生研究院 NHRI:Item 3990099045/5428
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5428


    Title: Lipopolysaccharide-stimulated activation of murine DC2.4 cells is attenuated by n-butylidenephthalide through suppression of the NF-kappa B pathway
    Other Titles: Lipopolysaccharide-stimulated activation of murine DC2.4 cells is attenuated by n-butylidenephthalide through suppression of the NF-κB pathway
    Authors: Fu, RH;Hran, HJ;Chu, CL;Huang, CM;Liu, SP;Wang, YC;Lin, YH;Shyu, WC;Lin, SZ
    Contributors: Immunology Research Center
    Abstract: Modulation of dendritic cell (DC) fate and function may be one approach for the treatment of inflammatory and autoimmune diseases. n-Butylidenephthalide (BP), derived from Angelica sinensis, at 40?μg/ml significantly decreased the secretion of interleukin-6 and tumor necrosis factor-α by lipopolysaccharide (LPS)-stimulated activation of cultured murine DC2.4 cells (P?<?0.01). LPS-induced major histocompatibility complex class II (P?<?0.05), CD86 (P?<?0.01) and CD40 (P?<?0.01) expression on DC2.4 cells was also inhibited by BP. The endocytic capacity of LPS-stimulated DC2.4 cells was increased by BP (P?<?0.01). The antigen-presenting capacity of LPS-stimulated DC2.4 cells was decreased by BP (P?<?0.05). Moreover, we confirmed BP attenuates the responses of LPS-stimulated activation of DCs via suppression of NF-κB-dependent pathways.
    Date: 2011-05
    Relation: Biotechnology Letters. 2011 May;33(5):903-910.
    Link to: http://dx.doi.org/10.1007/s10529-011-0528-5
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0141-5492&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000289897100006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79955123540
    Appears in Collections:[Ching-Liang Chu(2005-2010)] Periodical Articles

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