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    日期題名關聯
    2024-06-01 Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus Molecular Cancer Therapeutics. 2024 Jun 01;23(6):766-779.
    2023-12 Pulmonary delivery of remdesivir and dexamethasone encapsulated nanostructured lipid carriers for enhanced inflammatory suppression in lung Journal of Drug Delivery Science and Technology. 2023 Dec;90:Article number 105144.
    2023-01 Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists Bioorganic Chemistry. 2023 Jan;130:Article number 106236.
    2021-06-11 Synergistic inhibition of SARS-CoV-2 replication using disulfiram/ebselen and remdesivir[Erratum:ACS Pharmacology and Translational Science. 2021 Apr 9;4(2):898-907.] ACS Pharmacology and Translational Science. 2021 Jun 11;4(3):Article number 1246.
    2021-05-19 Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins Journal of Medicinal Chemistry. 2021 May 19;64(11):7312-7330.
    2021-04-09 Synergistic inhibition of SARS-CoV-2 replication using disulfiram/ebselen and remdesivir ACS Pharmacology and Translational Science. 2021 Apr 9;4(2):898-907.
    2020-12-14 Inhibition of SARS-CoV-2 by highly potent broad-spectrum anti-coronaviral tylophorine-based derivatives Frontiers in Pharmacology. 2020 Dec 14;11:Article number 606097.
    2020-10-08 Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery Scientific Reports. 2020 Oct 8;10:Article number 16771.
    2020-08 BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification Cancer Research. 2020 Aug;80(16):1937.
    2019-07 An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 3851.
    2019-01-01 Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist Bioorganic and Medicinal Chemistry. 2019 Jan 1;27(1):216-223.
    2018-05-10 Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition European Journal of Medicinal Chemistry. 2018 May 10;151:533-545.
    2016-12-08 Bromomethylthioindole inspired carbazole hybrids as promising class of anti-MRSA agents ACS Medicinal Chemistry Letters. 2016 Dec 8;7(12):1191-1196.
    2015-05 A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis Diabetes, Obesity and Metabolism. 2015 May;17(5):495-504.
    2015-03 Stem cell mobilizers targeting chemokine receptor CXCR4: Renoprotective application in acute kidney injury Journal of Medicinal Chemistry. 2015 Mar;58(5):2315-2325.
    2015-02-24 Pyrazole compounds US8962845/2015-02-24
    2015-02-11 吡唑類化合物 I472514/2015-02-11
    2015-02 Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors Journal of Medicinal Chemistry. 2015 Feb;58(3):1452-1465.
    2014-07-30 Pyrazole compounds ZA201303800B/2014-07-30
    2013-11-13 Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice Journal of Medicinal Chemistry. 2013 Nov 13;56(24):9920-9933.
    2012-07 Induction of fatty acid oxidation resists weight gain, ameliorates hepatic steatosis and reduces cardiometabolic risk factors International Journal of Obesity. 2012 Jul;36(7):999-1006.
    2012-02 Discovery of novel stem cell mobilizers that target the CXCR4 receptor ChemMedChem. 2012 Feb;7(2):209-212.
    2011-07 Conia-ene annulation of the alpha-cyano Beta-TMS-capped alkynyl cycloalkanone system and its synthetic application Organic and Biomolecular Chemistry. 2011 Jul;9(13):4778-4781.
    2010-09 Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist ChemMedChem. 2010 Sep;5(9):1439-1443.
    2009-07-23 Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4496-4510.
    2008-09-11 Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists Journal of Medicinal Chemistry. 2008 Sep 11;51(17):5397-5412.

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