國家衛生研究院 NHRI:Item 3990099045/5392
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 912549      線上人數 : 1231
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/5392


    題名: Differential effects of arsenic on cyp1 enzymes in vitro and in vivo
    作者: Wu, JP;Chang, LW;Lin, PP;Yao, HT;Chang, H;Wang, YJ;Yeh, TK;Tsai, MH;Tsai, HT
    貢獻者: Division of Environmental Health and Occupational Medicine;Institute of Biotechnology and Pharmaceutical Research
    摘要: Epidemiological studies provided strong indications that there was interaction between cigarette smoke and arsenic in the elevation of lung cancer risk among cigarette smoker in arseniasis areas. Animal studies also demonstrated an increased BaP-DNA adducts in lung tissues from animals co-exposed to BaP and arsenic. BaP is a cigarette smoke component and a known potent carcinogen, such enhancement of its carcinogenicity in lungs may be explained by enhancements of its metabolic activation (metabolites and DNA-adduct formation) in the presence of arsenic. We have investigated the influences of arsenic on the P450 CYP1A1 and CYP1B1 enzymes which were the primary metabolizing enzymes for BaP. We found that arsenic increased the CYP1A1, but not CYP1B1, mRNA expression in lung cells both in vitro and in vivo. When the CYP1 enzyme activity was measure, we found that The CYP1 enzyme activity was, as observed by other laboratories, decreased in vitro in the presence of arsenic. However, this enzyme activity was elevated in vivo as reflected by the up-regulation of Cyp1a1 mRNA expression. This opposing findings between in vitro and in vivo observations appeared to be paradoxical. Heme oxygenase 1 (HO-1) was known to degrade the CYP1 enzyme post-translationally. Indeed, our investigation further demonstrated that the HO-1 expression was up-regulated in vitro, but not in vivo, in the presence of arsenic. Our finding provided important scientific evidence which can explain the apparent paradoxical observations on a suppressed CYP1 activity by arsenic in in vitro studies and yet an enhanced BaP metabolism and BaP-DNA adducts in animals co-exposed to BaP and arsenic.
    日期: 2007-10
    關聯: Drug Metabolism Reviews. 2007 Oct;39(Suppl. 1):209.
    Link to: http://issx.confex.com/issx/intl8/webprogram/Paper5881.html
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0360-2532&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000283444100204
    顯示於類別:[林嬪嬪] 會議論文/會議摘要
    [張惠華(1999-2009)] 會議論文/會議摘要
    [葉燈光] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000283444100204.pdf106KbAdobe PDF608檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋