國家衛生研究院 NHRI:Item 3990099045/5388
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5388


    Title: Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin
    Authors: Hsu, CC;Wahlqvist, ML;Lee, MS;Tsai , HN
    Contributors: Division of Health Policy Research and Development
    Abstract: To determine incidence of dementia in type 2 diabetic (T2DM) patients, and whether there are adverse or favorable effects of oral agents (OA) in DM, we obtained a representative cohort of 800,000 from Taiwan's National Health Insurance database. Those who, as of on January 1, 2000, were 50 years or older and dementia free (n = 127,209) were followed until December 31, 2007, in relation to absence (n = 101,816) or presence (n = 25,393) of T2DM, and whether any OA was used. Dementia was ascertained by ICD9-CM or A-code. Dementia incidence densities (DID) and fully adjusted Cox proportional hazard models were used to estimate association between dementia, DM, and OA. Notably, DID (per 10,000 person-years) was markedly increased with DM (without medication), compared to DM free subjects (119 versus 46). Using non-DM as reference, the adjusted hazard ratios (HRs) (95% confidence interval) for DM without and with OA were 2.41 (2.17-2.66) and 1.62 (1.49-1.77), respectively. For T2DM, compared with no medication, sulfonylureas alone reduced the HR from 1 to 0.85 (0.71-1.01), metformin alone to 0.76 (0.58-0.98), while with combined oral therapy the HR was 0.65 (0.56-0.74). Adjustments included cerebrovascular diseases so that non-stroke related dementias were found to be decreased in DM with sulfonylurea and metformin therapy. T2DM increases the risk of dementia more than 2-fold. On the other hand, sulfonylureas may decrease the risk of dementia, as does metformin; together, these 2 OAs decrease the risk of dementia in T2DM patients by 35% over 8 years.
    Date: 2011-05
    Relation: Journal of Alzheimer's Disease. 2011 May;24(3):409-413.
    Link to: http://dx.doi.org/10.3233/jad-2011-101524
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1387-2877&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000292496900006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79956277464
    Appears in Collections:[Chih-Cheng Hsu] Periodical Articles
    [MARK LAWRENCE WAHLQVIST(2008-2012)] Periodical Articles

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