國家衛生研究院 NHRI:Item 3990099045/5350
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 911311      在线人数 : 907
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/5350


    题名: In-vivo investigation of the effects of ultrasound contrast agent and focused ultrasound on blood-brain barrier disruption
    作者: Yang, FY;Fu, WM;Liou, HC;Chen, WS;Lin, WL
    贡献者: Division of Medical Engineering Research
    摘要: In this study, the effects of UCA injection and ultrasound pressure on BBB disruption were investigated. Sonications were applied with an ultrasound frequency of 1 MHz, a burst length of 10ms at 1% duty cycle, and a repetition frequency of 1 Hz. The duration of the whole sonication was 30s. In-vivo experiments, twelve male Wistar rats were sonicated with four different UCA injections (0, 30, 60, 90 μL/kg). BBB integrity was evaluated via femoral vein injection of Evans Blue (EB) while rats were anesthetized. The relationship between the UCA injection and the region of EB flux was evaluated under 1.9 and 2.5 MPa ultrasound pressure. The BBB disruption, as indexed by EB flux, was significantly greater in rats injected with 60 or 90μL/kg UCA as compared to 0 or 30μL/kg injection. The amount of EB flux systematically increased as a function of the injection of UCA injected into the femoral vein before sonication. Furthermore, the BBB disruption could be concentrated in the focal region relative to the neighboring tissue with a higher injection of UCA (60 or 90μL/kg). This study demonstrates that an appropriate injection of UCA could effectively increase and localize the BBB disruption in the focal region for ultrasound sonication.
    日期: 2006-10
    關聯: IEEE Ultrasonics Symposium. 2006 Oct;1:1592-1595.
    Link to: http://dx.doi.org/10.1109/ULTSYM.2006.403
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000260407801011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=65649113434
    显示于类别:[其他] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP65649113434.pdf423KbAdobe PDF633检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈