國家衛生研究院 NHRI:Item 3990099045/5345
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    题名: Dendritic cell, toll-like receptor, and the immune system
    作者: Liu, KJ
    贡献者: National Institute of Cancer Research
    摘要: Dendritic cells (DCs) comprise a complex lineage and subset of bone marrow-derived antigen-presenting cells. DCs not only directly participate in the defense of microbial pathogens in the innate immune system; they also transmit the information of the invading pathogens and present pathogen antigens to T cells of the adaptive immune system and modulate subsequent immune responses. One critical factor for DCs to discriminate antigens derived from dead tissue cells or pathogens is the co-presence of certain pathogen-associated molecular patterns. DCs express several pattern-recognition receptors including the toll-like receptors. DCs use different toll-like receptors to simultaneously detect several features of the pathogens. Signals generated from various toll-like receptors coordinately regulate the production of distinct cytokines and determine the nature of the resulting immune responses. Thus, the ligands of toll-like receptors or toll-like receptor agonists are potent stimulators of the immune system. Several pharmaceutical companies are now exploring the application of toll-like receptor agonists in the treatment of several diseases including cancers. Preliminary results suggest that this kind of strategy may provide a new direction of immunotherapy.
    日期: 2006
    關聯: Journal of Cancer Molecules. 2006;2(6):213-215.
    Link to: http://mupnet.com/JOCM%202%286%29%20213.htm
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