國家衛生研究院 NHRI:Item 3990099045/5305

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Title:	Antitubercular resorcinol analogs and benzenoid C-glucoside from the roots of ardisia cornudentata
Authors:	Chang, CP;Chang, HS;Peng, CF;Lee, SJ;Chen, IS
Contributors:	Institute of Biotechnology and Pharmaceutical Research所
Abstract:	Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1′-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by analysis of spectroscopic data. Thirteen of these isolates, 1, 2, 4-6, 9-15, and 21 showed antitubercular activities against Mycobacterium tuberculosis H37R<sub>V</sub> in vitro, with MIC values of 2.5-60 μg/mL. Two alkyl benzoquinones, ardisianone (7) and cornudentanone (8), were reported for their selective cytotoxic activity against the NCI-H460 cancer cell line (IC<sub>50</sub> values of 2.3, 2.5 μg/mL).
Date:	2011-01
Relation:	Planta Medica. 2011 Jan;77(1):60-65.
Link to:	http://dx.doi.org/10.1055/s-0030-1250094
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0032-0943&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000285406500012
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78650050462
Appears in Collections:	[Shiow-Ju Lee] Periodical Articles

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