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http://ir.nhri.org.tw/handle/3990099045/5299
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| Title: | Post-coital vaginal douching is risky for non-regression of low-grade squamous intraepithelial lesion of the cervix |
| Authors: | Chu, TY;Hsiung, CA;Chen, CA;Chou, HH;Ho, CM;Chien, TY;Chang, HJ;Chou, CY;Liou, JD;Kan, YY;Hsieh, CY |
| Contributors: | Division of Biostatistics and Bioinformatics |
| Abstract: | Background: Vaginal douching is a common practice worldwide. Its effect on the natural history of the early lesion of human papillomavirus (HPV) infection, low-grade squamous intraepithelial lesion (LSIL), is unknown. Methods: In a prospective nation-wide cohort (n = 1332), epidemiological variables including habit of vaginal douching after intercourse and outcomes of LSIL were studied. Colposcopy-confirmed LSIL women (n = 295) were followed every 3 months. Parameters of HPV infection, sexual behavior, personal hygiene and environmental exposures were compared with the follow-up outcomes. Results: There was a 15% chance of HSIL co-existing with the LSIL cytology result. Eight percent of colposcopy-confirmed LSIL were found with HSIL in 1 year. With a follow-up of up to 36 months, 83% LSIL regressed, 11% progressed and 6% persisted. The mean time (95% CIs) to regression and progression were 5.2 (4.7-5.8) and 8.0 (5.8-10.3) months, respectively. Risk factors of the non-regression of LSIL included HPV prevalence on enrollment, habit of vaginal douching after intercourse with a hygiene product and non-regular Pap screening, with odd ratio of 4.4 (1.9-10.3), 3.14 (1.04-9.49) and 2.12 (1.24-3.62), respectively. HPV prevalence and vaginal douching also conferred a slower regression of LSIL (8.0 vs. 4.1 months, P < .001 and 8.0 vs. 5.6 months, P = 0.02, respectively). Conclusion: The study disclosed a transient but warning nature of cytological LSIL. Practicing of vaginal douching after intercourse, especially with hygiene products, is associated with non-regression of LSIL. |
| Date: | 2011-03 |
| Relation: | Gynecologic Oncology. 2011 Mar;120(3):449-453. |
| Link to: | http://dx.doi.org/10.1016/j.ygyno.2010.11.006 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0090-8258&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000287563600023 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79951577440 |
| Appears in Collections: | [熊昭] 期刊論文
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| SCP78649706972.pdf | | 140Kb | Adobe PDF | 669 | View/Open |
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