國家衛生研究院 NHRI:Item 3990099045/5243
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5243


    Title: Association study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder
    Authors: Xu, X;Breen, G;Chen, CK;Huang, YS;Wu, YY;Asherson, P
    Contributors: Division of Mental Health and Addiction Medicine
    Abstract: BACKGROUND: The circadian locomotor output cycles kaput (CLOCK) gene encodes protein regulation circadian rhythm and also plays some roles in neural transmitter systems including the dopamine system. Several lines of evidence implicate a relationship between attention-deficit hyperactivity disorder (ADHD), circadian rythmicity and sleeping disturbances. A recent study has reported that a polymorphism (rs1801260) at the 3'-untranslated region of the CLOCK gene is associated with adult ADHD. METHODS: To investigate the association between the polymorphism (rs1801260) in ADHD, two samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212) were genotyped and analysed using within-family transmission disequilibrium test (TDT). Bonferroni correction procedures were used to just for multiple comparisons. RESULTS: We found evidence of increased transmission of the T allele of the rs1801260 polymorphism in Taiwanese samples (P = 0.010). There was also evidence of preferential transmission of the T allele of the rs1801260 polymorphism in combined samples from the Taiwan and UK (P = 0.008). CONCLUSION: This study provides evidence for the possible involvement of CLOCK in susceptibility to ADHD.
    Date: 2010-08
    Relation: Behavioral and Brain Functions. 2010 Aug;6:48.
    Link to: http://dx.doi.org/10.1186/1744-9081-6-48
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1744-9081&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000281434900001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955380005
    Appears in Collections:[Others] Periodical Articles

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