國家衛生研究院 NHRI:Item 3990099045/5213

NHRI > National Institute of Infectious Diseases and Vaccinology > Tsai-Ling Yang Lauderdale > Periodical Articles > Item 3990099045/5213

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Title:	Risk factors for mortality of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection: With investigation of the potential role of community-associated MRSA strains
Authors:	Wang, JT;Wang, JL;Fang, CT;Chie, WC;Lai, MS;Lauderdale, TL;Weng, CM;Chang, SC
Contributors:	Division of Infectious Diseases
Abstract:	Objectives: The difference in the outcomes of nosocomial bloodstream infection (BSI) caused by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains and healthcare-associated MRSA (HA-MRSA) strains remains unclear. Methods: From January 1, 2006 to December 31, 2008, all adult patients hospitalized at National Taiwan University Hospital with nosocomial MRSA BSI were analyzed. Available MRSA isolates were submitted for subsequent microbiologic studies to determine whether they belonged to CA-MRSA strains. Results: In total, 308 patients were enrolled and 253 MRSA isolates were available. Forty-seven isolates belonged to CA-MRSA strains. The all-cause mortality rates on Day 14 and Day 30 were 19.8% and 30.5%, respectively, and were not different between those caused by CA-MRSA and HA-MRSA strains. The independent risk factors for Day 14 mortality were septic shock, thrombocytopenia, and an inadequate serum trough level of vancomycin (p?=?<0.0001, 0.0003, and 0.0381, respectively). Those for Day 30 mortality were septic shock, anemia, thrombocytopenia, presence of underlying malignancies, and MRSA isolates with a vancomycin minimum inhibitory concentration of 2?mg/L (p?=?<0.0001, 0.0425, 0.0007, 0.0098, and 0.0012, respectively). Conclusions: The mortality rates of nosocomial MRSA BSI were not different between that caused by CA-MRSA and HA-MRSA strains.
Date:	2010-12
Relation:	Journal of Infection. 2010 Dec;61(6):449-457.
Link to:	http://dx.doi.org/10.1016/j.jinf.2010.09.029
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0163-4453&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000284691500002
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78649634980
Appears in Collections:	[Tsai-Ling Yang Lauderdale] Periodical Articles

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