國家衛生研究院 NHRI:Item 3990099045/5112
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    题名: Dendritic cell activation by recombinant hemagglutinin proteins of H1N1 and H5N1 influenza A viruses
    作者: Liu, WC;Lin, SC;Yu, YL;Chu, CL;Wu, SC
    贡献者: Vaccine Research and Development Center
    摘要: Since dendritic cells may play a key role in defenses against influenza virus infection, we examined the effects of recombinant hemagglutinin (HA) proteins derived from mouse-adapted H1N1 (A/WSN/1933), swine-origin 2009 pandemic H1N1 (A/Texas/05/2009), and high-pathogenic avian influenza H5N1 (A/Thailand/KAN-1/2004) viruses on mouse myeloid dendritic cells (mDCs). The results reveal that TNF-alpha, IL-12 p70, and MHC II expression were increased in mDCs after the treatments with recombinant HA proteins of H1N1 and H5N1. The specificity of recombinant HA treatments on mDC activation was diminished after protein K digestion. HA apparently promotes mDC maturation by enhancing CD40 and CD86 expression and suppressing endocytosis. No significant differences in mDCs activation were observed among recombinant proteins of H1N1 and H5N1. The stimulation of HA proteins of H1N1 and H5N1 on mDCs was all MyD88 dependent. These findings may provide useful information for the development of more effective influenza vaccines.
    日期: 2010-11
    關聯: Journal of Virology. 2010 Nov;84(22):12011-12017.
    Link to: http://dx.doi.org/10.1128/jvi.01316-10
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-538X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000283420500040
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78049492732
    显示于类别:[朱清良(2005-2007)] 期刊論文

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