國家衛生研究院 NHRI:Item 3990099045/5106
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    题名: Selective inhibition of early-but not late-expressed HIF-1alpha is neuroprotective in rats after focal ischemic brain damage
    其它题名: Selective inhibition of early-but not late-expressed HIF-1α is neuroprotective in rats after focal ischemic brain damage
    作者: Yeh, SH;Ou, LC;Gean, PW;Hung, JJ;Chang, WC
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Abstract The expression of hypoxia-inducible factor-1-alpha (HIF-1α) is up-regulated in ischemic stroke, but its function is still unclear. In the present study, biphasic expression of HIF-1α was observed during 1 to 12 h and after 48 h in neurons exposed to ischemic stress in vitro and in vivo. Treating neurons with 2-methoxyestradiol (2ME2) 0.5 h after ischemic stress or pre-silencing HIF-1α with siRNA decreased brain injury, brain edema, number of apoptotic cell and down-regulate Nix expression. Conversely, apply 2ME2 to neurons 8 h after ischemic stress or silencing the HIF-1α with siRNA 12 h after OGD increased neuron damage and decreased vascular endothelial growth factor (VEGF) expression. Taken together, these results demonstrate HIF-1α induced by ischemia in early and late time leads cellular apoptosis and survival respectively, and provides a new insight into the divergent roles of HIF-1α expression in neurons after ischemic stroke.
    日期: 2011-05
    關聯: Brain Pathology. 2011 May;21(3):249-262.
    Link to: http://dx.doi.org/10.1111/j.1750-3639.2010.00443.x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1015-6305&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000289521600002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79954594089
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