國家衛生研究院 NHRI:
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    显示项目1-10 / 25. (共3页)
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    日期题名關聯
    2024-10-29 DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration Journal of Medicinal Chemistry. 2024 Oct 29;Article in Press.
    2024-07-17 Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia Cell Chemical Biology. 2024 Jul 17;Article in Press.
    2023-10-05 A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115608.
    2022-12-05 Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728.
    2022-11 Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone Bioorganic Chemistry. 2022 Nov;128:Article number 105905.
    2020-10-08 Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery Scientific Reports. 2020 Oct 8;10:Article number 16771.
    2020-10 Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma Neuro-Oncology. 2020 Oct;22(10):1439-1451.
    2020-06 Morphine produces potent antinociception, sedation, and hypothermia in humanized mice expressing human mu opioid receptor splice variants Pain. 2020 Jun;161(6):1177-1190.
    2020-04-15 Betulinic acid-mediated tuning of PERK/CHOP signaling by Sp1 inhibition as a novel therapeutic strategy for glioblastoma Cancers. 2020 Apr 15;12(4):Article number 981.
    2020-04 BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine Neuropharmacology. 2020 Apr;166:Article number 107678.

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