國家衛生研究院 NHRI:Item 3990099045/5048
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5048


    Title: A phase II and pharmacokinetic study of first line S-1 for advanced gastric cancer in Taiwan
    Authors: Chen, JS;Chao, Y;Hsieh, RK;Cheng, AL;Chen, PM;Chiou, TJ;Chao, TY;Yeh, KH;Chen, LT;Whang-Peng, J
    Contributors: National Institute of Cancer Research
    Abstract: PURPOSE: To evaluate the efficacy, safety and pharmacokinetic profiles of S-1, which composed of tegafur (FT, a prodrug of 5-FU), 5-chloro-2,4-dihydroxypyridine and potassium oxonate (Oxo), in Taiwanese advanced gastric cancer (AGC) patients. METHODS: Patients with chemo-naive, histologically confirmed AGC were eligible. S-1 was given orally at dose of 40, 50 or 60 mg, twice daily for patients with body surface <1.25, 1.25-1.5 and >1.5 m(2), respectively, on day 1-28 every 42 days/cycle. RESULTS: Thirty-four patients were included. On intent-to-treat analysis, the overall response rate, median progression-free and overall survival were 35.3% [95% confidence interval (CI): 19.2-51.3%], 2.9 (95% CI: 2.4-5.8) months and 9.8 (95% CI: 6.1-NA) months, respectively. The most common grade 3-4 toxicities were anemia 23.5% and neutropenia 11.8%. There were two treatment-related mortality, which occurred in patients with suboptimal renal function underestimated by serum creatinine level at study entry. Single-dose pharmacokinetic study showed trend toward lower AUC(5-FU), and higher AUC(FT) and AUC(Oxo) comparing to most Western reports. CONCLUSIONS: The efficacy, toxicity and pharmacokinetic profiles of S-1 in current study are compatible with those from other Asian populations. Accurate renal function assessment and more closely monitoring is mandatory for S-1 therapy in patients with low body mass. Literature review suggests that, besides AUC(5-FU), AUC(Oxo) may also attribute to the difference in the compliance to S-1 between Asian and Caucasian populations.
    Date: 2011-08-17
    Relation: Cancer Chemotherapy and Pharmacology. 2011 Aug 17;67(6):1281-1289.
    Link to: http://dx.doi.org/10.1007/s00280-010-1416-8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0344-5704&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000291036500008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79959581533
    Appears in Collections:[Li-Tzong Chen] Periodical Articles
    [Jacqueline Whang-Peng(1996-2007)] Periodical Articles

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