國家衛生研究院 NHRI:Item 3990099045/5027
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 862364      在线人数 : 480
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/5027


    题名: Emergence and distribution of plasmids bearing the blaOXA-51-like gene with an upstream ISAba1 in carbapenem-resistant acinetobacter baumannii isolates in Taiwan
    作者: Chen, TL;Lee, YT;Kuo, SC;Hsueh, PR;Chang, FY;Siu, LK;Ko, WC;Fung, CP
    贡献者: Division of Infectious Diseases
    摘要: The ISAba1- blaOXA-51-like gene was originally found on the chromosome of carbapenem resistant or susceptible Acinetobacter baumannii. However, plasmids borne ISAba1- blaOXA-51-like gene has recently been identified in an Acinetobacter genomic species 13TU and several A. baumannii isolates in Taiwan, and all of the isolates are carbapenem resistant. This study aimed to characterize the plasmids bearing ISAba1- blaOXA-51-like and their significance in A. baumannii. Among the 117 ISAba1- blaOXA-51-like harboring isolates collected from 10 hospitals in Taiwan, 58 (49.6%) isolates from 24 clones had the genes located on plasmids that likely originated from a common progenitor. Among the 58 isolates, four had additional copy of ISAba1- blaOXA-51-like on their chromosomes. Based on the analysis of these four isolates, the plasmids located ISAba1- blaOXA-51-like appeared to be acquired via one-ended transposition (Tn6080). The isolates with a plasmid bearing ISAba1- blaOXA-51-like had a higher resistance rate to imipenem (98% vs. 46.6%, p < 0.001) and meropenem (98% vs. 69%, p = 0.019) compared with those with the genes chromosomally encoded, which is most likely due to increased gene dosage provided by the higher copy number of associated plasmids. Transformation with a recombinant plasmid harboring only ISAba1- blaOXA-51-like was enough to confer a high level of carbapenem resistance to A. baumannii, eliminating the possible contribution of other factors on the original plasmids. This study demonstrated that the carbapenem resistance associated plasmids carrying ISAba1- blaOXA-51-like are widespread in A. baumannii in Taiwan.
    日期: 2010-11
    關聯: Antimicrobial Agents and Chemotherapy. 2010 Nov;54(11):4575-4581.
    Link to: http://dx.doi.org/10.1128/aac.00764-10
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0066-4804&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000284155000009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78049311277
    显示于类别:[蕭樑基] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    PUB20713680.pdf913KbAdobe PDF612检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈