國家衛生研究院 NHRI:Item 3990099045/5009
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    题名: Cytotoxic flavonoids from the leaves of cryptocarya chinensis
    作者: Chou, TH;Chen, JJ;Lee, SJ;Chiang, MY;Yang, CW;Chen, IS
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: Bioassay-guided fractionation led to the isolation of six new tetrahydroflavanones, cryptochinones A-F (1-6), from the neutral CHCl(3) fraction of Cryptocarya chinensis leaves, together with 14 known compounds (7-20). The structures of these new compounds were determined through spectroscopic analyses, including 2D-NMR, MS, CD, and X-ray crystallographic analysis. Among the isolates, infectocaryone (7) showed cytotoxic activities with IC(50) values of 11.0 and 3.7 muM against NCI-H460 and SF-268 cell lines, respectively, and cryptocaryanone A (9) showed cytotoxic activities with IC(50) values of 5.1, 4.3, and 5.0 muM against MCF-7, NCI-H460, and SF-268 cell lines, respectively.
    日期: 2010-09
    關聯: Journal of Natural Products. 2010 Sep;73(9): 1470-1475.
    Link to: http://dx.doi.org/10.1021/np100014j
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0163-3864&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000282038800003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77957245245
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