國家衛生研究院 NHRI:Item 3990099045/4967
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    题名: Clinical manifestations, antimicrobial therapy, and prognostic factors of monomicrobial Acinetobacter baumannii complex bacteremia
    作者: Lee, NY;Chang, TC;Wu, CJ;Chang, CM;Lee, HC;Chen, PL;Lee, CC;Ko, NY;Ko, WC
    贡献者: Division of Infectious Diseases
    摘要: Objectives: Bacteremia due to Acinetobacter baumannii complex (ABC), which composed of four genomic species (gen. sp.), is a serious and potentially fatal condition. The epidemiology and outcome of such infections due to individual gen. sp. remain undefined. Methods: A retrospective study of patients with monomicrobial ABC bacteremia over six years was conducted at a medical center to determine the association of gen. sp. with clinical outcome. Results: Included were 291 patients with monomicrobial ABC bacteremia. Of them, 222 (76.3%) patients had bacteremia caused by gen. sp. 2, i.e. A. baumannii. The presence of multidrug-resistant phenotype was the only independent predictor of Acinetobacter gen. sp. 2 bacteremia (adjusted odd ratio, 7.5; 95% confidence interval, 3.8-14.7; P?<?0.001). Patients with Acinetobacter gen. sp. 2 bacteremia had a higher sepsis-related (P?=?0.006) and 30 day (P?=?0.028) mortality rates than the non-Acinetobacter gen. sp. 2 group. The fatal outcome was independently associated with high SPAS II scores (P?=?0.002), rapidly fatal underlying diseases (P?=?0.002), bacteremia caused by Acinetobacter gen. sp. 2 (P?=?0.01), inappropriate definitive antimicrobial therapy (P?<?0.001), and severe sepsis (P?<?0.001). Conclusion: Acinetobacter gen. sp. 2 bacteremia heralded a worse clinical outcome, and therefore the gen. sp. identification of ABC bacteremic isolates is justified. c 2010 The British Infection Society.
    日期: 2010-09
    關聯: Journal of Infection. 2010 Sep; 61(3):219-227.
    Link to: http://dx.doi.org/10.1016/j.jinf.2010.07.002
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0163-4453&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000280895500004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955660163
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