國家衛生研究院 NHRI:Item 3990099045/4960

NHRI > Institute of Biotechnology and Pharmaceutical Research > Kak-Shan Shia > Periodical Articles > Item 3990099045/4960

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4960

Title:	Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophe n-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist
Authors:	Hung, MS;Chang, CP;Li, TC;Yeh, TK;Song, JS;Lin, Y;Wu, CH;Kuo, PC;Amancha, PK;Wong, YC;Hsiao, WC;Chao, YS;Shia, KS
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	Fast food nation! The title compound (pictured) was identified as a potential peripheral CB1-acting antagonist based on its negative central effects in CB1R agonist-induced hypothermia and analgesia models, and low brain exposure as indicated by the blood-to-plasma ratio. This compound represents a potential lead in the treatment of metabolic disorders.
Date:	2010-09
Relation:	ChemMedChem. 2010 Sep;5(9):1439-1443.
Link to:	http://dx.doi.org/10.1002/cmdc.201000246
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1860-7179&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000281918400004
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77956411564
Appears in Collections:	[Kak-Shan Shia] Periodical Articles [Yu-Sheng Chao(2002-2013)] Periodical Articles [Teng-Kuang Yeh] Periodical Articles [Ming-Shiu Hung] Periodical Articles [Chun-Ping Chang] Periodical Articles

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