國家衛生研究院 NHRI:Item 3990099045/4955
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4955


    Title: ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment
    Authors: Lin, KM;Chiu, YF;Tsai, IJ;Chen, CH;Shen, WW;Liu, SC;Lu, SC;Liu, CY;Hsiao, MC;Tang, HS;Liu, SI;Chang, LH;Wu, CS;Tsou, HH;Tsai, MH;Chen, CY;Wang, SM;Kuo, HW;Hsu, YT;Liu, YL
    Contributors: Division of Mental Health and Addiction Medicine;Division of Biostatistics and Bioinformatics
    Abstract: OBJECTIVE: ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) is a drug transporter protein expressed on the epithelial cells of the intestine and the endothelial cells of the blood-brain barrier. Intestinal ABCB1 actively transports drugs from the cell membrane and prevents them from entering the blood stream whereas the blood-brain barrier ABCB1 prevents drugs from entering the central nervous system. In this study, we tested whether genetic polymorphisms within the ABCB1 gene are associated with the severity of depression and the effectiveness of the antidepressant, escitalopram (S-CIT), in treating major depressive disorder (MDD). METHODS: Twenty single nucleotide polymorphisms in the ABCB1 gene were selected and genotyped in 100 MDD patients who had undergone S-CIT treatment continuously for 8 weeks. The serum concentrations of S-CIT and its metabolites (S-desmethylcitalopram and S-didesmethylcitalopram) were then measured at weeks 2, 4, and 8. RESULTS: The ABCB1 genotypes of rs1922242 (P=0.0028) and rs1202184 (P=0.0021) showed significant association with the severity of depressive symptoms as assessed by the Hamilton Rating Scale for Depression adjusted with Hamilton Rating Scale for Anxiety. The haplotype block, rs1882478-rs2235048-rs2235047-rs1045642-rs6949448 (from intron 27 to intron 26), of ABCB1 was found strongly associated with the remission rate (global P=0.003, d.f.=69) in which haplotype T-T-T-C-C was associated with a slower remission rate on S-CIT treatment (P=0.001). The haplotypes may not be indicators of the severity of depression or anxiety. CONCLUSION: Our findings suggest that single nucleotide polymorphisms in the ABCB1 gene may be indicators of the severity of depression and of the likely S-CIT treatment remission response in MDD.
    Date: 2011-04
    Relation: Pharmacogenetics and Genomics. 2011 Apr;21(4):163-170.
    Link to: http://dx.doi.org/10.1097/FPC.0b013e32833db216
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1744-6872&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000288444500001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79955472490
    Appears in Collections:[Keh-Ming Lin(2004-2009)] Periodical Articles
    [Yu-Li Liu] Periodical Articles
    [Yen-Feng Chiu] Periodical Articles
    [Hsiao-Hui Sophie Tsou] Periodical Articles

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