國家衛生研究院 NHRI:Item 3990099045/4948
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    題名: Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents
    作者: Hong, X.;Arguelles, LM;Liu, X.;Tsai, HJ;Hsu, YH;Wang, B.;Zhang, S.;Li, Z.;Tang, G.;Yang, J.;Xu, X.;Langman, C.;Wang, X.
    貢獻者: Division of Biostatistics and Bioinformatics
    摘要: This study was an attempt to examine the phenotypic, genetic, and environmental correlations between percent fat mass (PFM) and bone parameters, especially hip geometry, among 786 males and 618 females aged 13 to 21 years from a Chinese twin cohort. PFM, bone area (BA), bone mineral content (BMC), cross-sectional area (CSA), and section modulus (SM) were obtained by dual-energy X-ray absorptiometry. Multiple linear regression models were used to assess the PFM-bone relationships. A structural equation model for twin design was used to estimate genetic/environmental influences on individual phenotype and phenotypic correlations. After controlling for body weight and other pertinent covariates, we observed inverse associations between PFM and bone parameters: Compared with the lowest age- and gender-specific tertile of PFM, males in the highest tertile of PFM had lower measures of whole-body-less-head BA (WB-BA), lumbar spine BA (L2-L4-BA), total-hip BA (TH-BA), total-hip BMC, CSA, and SM (p?<?.005 for all, adjusted p?<?.05). Similar inverse associations were observed in females for all the preceding parameters except WB-BA and L2-L4-BA. These associations did not vary significantly by Tanner stages. In both genders, the estimated heritabilities were 80% to 86% for BMC, 67% to 80% for BA, 74% to 77% for CSA, and 64% for SM. Both shared genetics and environmental factors contributed to the inverse PFM-bone correlations. We conclude that in this sample of relatively lean Chinese adolescents, at a given body weight, PFM is inversely associated with BA, BMC, and hip geometry in both genders, and such associations are attributed to both shared genetic and environmental factors.
    日期: 2010-07
    關聯: Journal of Bone and Mineral Research. 2010 Jul;25(7):1544-1554.
    Link to: http://dx.doi.org/10.1002/jbmr.40
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0884-0431&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000280395900010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77954727537
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